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In the case of tirzepatide, Scherer believes the mechanism may relate to its GIPR action: Since tirzepatide is an imbalanced dual agonist with stronger GIPR action and weaker binding to GLP-1R compared to classic GLP-1 agonists, a GIP-mediated mechanism seems likely

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Safety and Side Effects Sermorelin is generally well-tolerated, with common side effects including mild headache, temporary nausea, and redness or swelling at the injection site

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doi:10.1155/2017/4179326 [85] Murata S, Inoue K, Aomatsu T, Yoden A, Tamai H